Our study demonstrates that different BAG 1 isoforms possess different abilities to suppress apoptosis in response to different apoptotic signals. Although forced expression of BAG 1 causes increased expression of Bcl 2, the anti apoptotic function of BAG 1 seems to be largely determined by its N terminal protein segment. The functional domains present on the N terminus determine the subcellular distribution of the BAG 1 isoforms in the nucleus and cytosol.
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